Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets

The endocochlear potential (EP) generated by the stria vascularis (SV) is necessary for hair cell mechanotransduction in the mammalian cochlea. We sought to create a model of EP dysfunction for the purposes of transcriptional analysis and treatment testing. By administering a single dose of cisplati...

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Detalles Bibliográficos
Autores principales: Taukulis, Ian A., Olszewski, Rafal T., Korrapati, Soumya, Fernandez, Katharine A., Boger, Erich T., Fitzgerald, Tracy S., Morell, Robert J., Cunningham, Lisa L., Hoa, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458580/
https://www.ncbi.nlm.nih.gov/pubmed/34566577
http://dx.doi.org/10.3389/fnmol.2021.718241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458580/
https://www.ncbi.nlm.nih.gov/pubmed/34566577
http://dx.doi.org/10.3389/fnmol.2021.718241

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