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Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway

Chidamide (CDM), a novel histone deacetylase inhibitor, is currently used for patients with peripheral T-cell lymphoma. Aspirin (ASA), an anti-inflammatory drug, has been shown to exert anticancer activity. Herein, we investigated the effect of CDM combined with ASA on myelodysplastic syndromes-deri...

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Detalles Bibliográficos
Autores principales: Liang, Simin, Zhou, Xiaojia, Cai, Duo, Rodrigues-Lima, Fernando, Chi, Jianxiang, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458633/
https://www.ncbi.nlm.nih.gov/pubmed/34568314
http://dx.doi.org/10.3389/fcell.2021.685954