Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypothalamic POMC (proopiomelanocortin) neurons and their...

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Detalles Bibliográficos
Autores principales: Perissinotti, Paula P., Martínez-Hernández, Elizabeth, He, Yungui, Koob, Michael D., Piedras-Rentería, Erika S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458657/
https://www.ncbi.nlm.nih.gov/pubmed/34566565
http://dx.doi.org/10.3389/fnins.2021.718464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458657/
https://www.ncbi.nlm.nih.gov/pubmed/34566565
http://dx.doi.org/10.3389/fnins.2021.718464

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