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Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypothalamic POMC (proopiomelanocortin) neurons and their...

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Detalles Bibliográficos
Autores principales:	Perissinotti, Paula P., Martínez-Hernández, Elizabeth, He, Yungui, Koob, Michael D., Piedras-Rentería, Erika S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458657/ https://www.ncbi.nlm.nih.gov/pubmed/34566565 http://dx.doi.org/10.3389/fnins.2021.718464

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