Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a breaking point, along with devastating socioeconomic consequences. The SARS-CoV-2 virus, which causes the disease, uses RNA capping to evade the human immune system. Nonstructural protein (nsp) 14 is one of the 16 nsps i...

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Detalles Bibliográficos
Autores principales: Devkota, Kanchan, Schapira, Matthieu, Perveen, Sumera, Khalili Yazdi, Aliakbar, Li, Fengling, Chau, Irene, Ghiabi, Pegah, Hajian, Taraneh, Loppnau, Peter, Bolotokova, Albina, Satchell, Karla J.F., Wang, Ke, Li, Deyao, Liu, Jing, Smil, David, Luo, Minkui, Jin, Jian, Fish, Paul V., Brown, Peter J., Vedadi, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Laboratory Automation and Screening. Published by Elsevier Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458670/
https://www.ncbi.nlm.nih.gov/pubmed/34192965
http://dx.doi.org/10.1177/24725552211026261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458670/
https://www.ncbi.nlm.nih.gov/pubmed/34192965
http://dx.doi.org/10.1177/24725552211026261

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