An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavir...

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Detalles Bibliográficos
Autores principales: Liu, Zezhong, Xu, Wei, Chen, Zhenguo, Fu, Wangjun, Zhan, Wuqiang, Gao, Yidan, Zhou, Jie, Zhou, Yunjiao, Wu, Jianbo, Wang, Qian, Zhang, Xiang, Hao, Aihua, Wu, Wei, Zhang, Qianqian, Li, Yaming, Fan, Kaiyue, Chen, Ruihong, Jiang, Qiaochu, Mayer, Christian T., Schoofs, Till, Xie, Youhua, Jiang, Shibo, Wen, Yumei, Yuan, Zhenghong, Wang, Kang, Lu, Lu, Sun, Lei, Wang, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458794/
https://www.ncbi.nlm.nih.gov/pubmed/34554412
http://dx.doi.org/10.1007/s13238-021-00871-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458794/
https://www.ncbi.nlm.nih.gov/pubmed/34554412
http://dx.doi.org/10.1007/s13238-021-00871-6

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