CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine

PURPOSE: The purpose of our research was to identify and evaluate synthetic phosphorothioate-modified CPG oligodeoxynucleotides (CPG-ODNs) activating innate and adaptive immune responses. Furthermore, combined treatment with CpG and an mRNA cancer vaccine was evaluated in melanoma models as a therap...

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Detalles Bibliográficos
Autores principales: Li, Qin, Ren, Jie, Liu, Wei, Jiang, Guoqin, Hu, Rongkuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459178/
https://www.ncbi.nlm.nih.gov/pubmed/34566407
http://dx.doi.org/10.2147/DDDT.S325790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459178/
https://www.ncbi.nlm.nih.gov/pubmed/34566407
http://dx.doi.org/10.2147/DDDT.S325790

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