SLC45A4 promotes glycolysis and prevents AMPK/ULK1‐induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma

BACKGROUND: Somatic mutations of the TP53 gene occur frequently in pancreatic ductal adenocarcinoma (PDA). Solute carrier family 45 member A4 (SLC45A4) is a H(+)‐dependent sugar cotransporter. The role of SLC45A4 in PDA, especially in TP53 mutant PDA, remains poorly understood. METHODS: We explored...

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Detalles Bibliográficos
Autores principales: Chen, Wenying, Huang, Fengting, Huang, Jing, Li, Yuanhua, Peng, Juanfei, Zhuang, Yanyan, Huang, Xianxian, Lu, Liting, Zhu, Zhe, Zhang, Shineng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459293/
https://www.ncbi.nlm.nih.gov/pubmed/34010493
http://dx.doi.org/10.1002/jgm.3364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459293/
https://www.ncbi.nlm.nih.gov/pubmed/34010493
http://dx.doi.org/10.1002/jgm.3364

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