ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens

High-throughput CRISPR-Cas9 knockout screens are widely used to evaluate gene essentiality in cancer research. Here we introduce a probabilistic modeling framework, Analysis of CRISPR-based Essentiality (ACE), that accounts for multiple sources of variation in CRISPR-Cas9 screens and enables new sta...

Descripción completa

Detalles Bibliográficos
Autores principales: Hutton, Elizabeth R., Vakoc, Christopher R., Siepel, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459512/
https://www.ncbi.nlm.nih.gov/pubmed/34556174
http://dx.doi.org/10.1186/s13059-021-02491-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459512/
https://www.ncbi.nlm.nih.gov/pubmed/34556174
http://dx.doi.org/10.1186/s13059-021-02491-z

Ejemplares similares