Cargando…

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases. The transferability of drug toxicity and efficacy estimates to humans from animal models is b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malik, Mridu, Yang, Yang, Fathi, Parinaz, Mahler, Gretchen J., Esch, Mandy B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459628/ https://www.ncbi.nlm.nih.gov/pubmed/34568333 http://dx.doi.org/10.3389/fcell.2021.721338

Ejemplares similares

3D organ-on-a-chip: The convergence of microphysiological systems and organoids
por: Baptista, Leandra S., et al.
Publicado: (2022)

The Development of Controllable Magnetic Driven Microphysiological System
por: Yang, Jia-Wei, et al.
Publicado: (2019)

A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development
por: Johnson, Brian P., et al.
Publicado: (2021)

Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)
por: Sung, Jong Hwan, et al.
Publicado: (2019)

Retinal Degeneration in MPS-IIIA Mouse Model
por: Intartaglia, Daniela, et al.
Publicado: (2020)

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration
por: Yu, J, et al.
Publicado: (2015)

Lost in transduction: Critical considerations when using viral vectors
por: Hines, William C., et al.
Publicado: (2023)

Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project
por: Ishida, Seiichi
Publicado: (2021)

Relationship between Adsorption and Toxicity of Nephrotoxic Drugs in Microphysiological Systems (MPS)
por: Ueno, Ryohei, et al.
Publicado: (2023)

Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate
por: Chen, Longyi, et al.
Publicado: (2020)

Tales of the ER-Golgi Frontier: Drosophila-Centric Considerations on Tango1 Function
por: Feng, Zhi, et al.
Publicado: (2021)

Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability
por: Rizzo, Marilena, et al.
Publicado: (2021)

Safety Considerations in the Development of Hippo Pathway Inhibitors in Cancers
por: Kakiuchi-Kiyota, Satoko, et al.
Publicado: (2019)

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities
por: Claridge, Bethany, et al.
Publicado: (2021)

Skin microbiome considerations for long haul space flights
por: Caswell, Gabrielle, et al.
Publicado: (2022)

Functional genomics in stem cell models: considerations and applications
por: Shevade, Kaivalya, et al.
Publicado: (2023)

Modelling Renal Filtration and Reabsorption Processes in a Human Glomerulus and Proximal Tubule Microphysiological System
por: Zhang, Stephanie Y., et al.
Publicado: (2021)

Ferroptosis: whERe is the critical site of lipid peroxidation?
por: Yang, Wan Seok
Publicado: (2023)

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury
por: Soffientini, Ugo, et al.
Publicado: (2021)

Therapeutic Effects of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Oxygen-Induced Multi-Organ Disease: A Developmental Perspective
por: Fernandez-Gonzalez, Angeles, et al.
Publicado: (2021)

Analysis of Neat Biofluids Obtained During Cardiac Surgery Using Nanoparticle Tracking Analysis: Methodological Considerations
por: Shearn, Andrew I. U., et al.
Publicado: (2020)

Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer
por: Sun, YuanLin, et al.
Publicado: (2022)

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
por: Moura, Margarida, et al.
Publicado: (2017)

Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective
por: Liu, Qiang, et al.
Publicado: (2017)

The Critical Role of Ferroptosis in Hepatocellular Carcinoma
por: Pan, Fan, et al.
Publicado: (2022)

ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis
por: Liu, Gaoke, et al.
Publicado: (2020)

Targeting the stem cell niche micro-environment as therapeutic strategies in aging
por: Farahzadi, Raheleh, et al.
Publicado: (2023)

Multi-Omics Analysis of Anlotinib in Pancreatic Cancer and Development of an Anlotinib-Related Prognostic Signature
por: Zhang, Xi, et al.
Publicado: (2021)

Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells
por: Tan, Zhenya, et al.
Publicado: (2022)

Transcriptome Reveals Multi Pigmentation Genes Affecting Dorsoventral Pattern in Avian Body
por: Xi, Yang, et al.
Publicado: (2020)

The Morphological Diversity of Plant Organs: Manipulating the Organization of Microtubules May Do the Trick
por: Bao, Zhiru, et al.
Publicado: (2021)

Profiling of RNA N(6)-Methyladenosine Methylation Reveals the Critical Role of m(6)A in Chicken Adipose Deposition
por: Cheng, Bohan, et al.
Publicado: (2021)

Critical Role of TLR4 on the Microglia Activation Induced by Maternal LPS Exposure Leading to ASD-Like Behavior of Offspring
por: Xiao, Lu, et al.
Publicado: (2021)

Single-cell and genetic multi-omics analysis combined with experiments confirmed the signature and potential targets of cuproptosis in hepatocellular carcinoma
por: Cao, Feng, et al.
Publicado: (2023)

Multi-Omics Analysis of the Therapeutic Value of MAL2 Based on Data Mining in Human Cancers
por: Yuan, Jing, et al.
Publicado: (2022)

Organ-Specific Branching Morphogenesis
por: Lang, Christine, et al.
Publicado: (2021)

Self-organization in amoeboid motility
por: Callan-Jones, Andrew
Publicado: (2022)

Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration
por: Sagaradze, Georgy D., et al.
Publicado: (2020)

Intracellular Ca(2 +) Imbalance Critically Contributes to Paraptosis
por: Kim, Eunhee, et al.
Publicado: (2021)

Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases
por: Beatriz, Margarida, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jqgoii3ctfp5d75sj1i34me9f9