Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

LRRK2 gain-of-function is considered a major cause of Parkinson’s disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus elicits a pleomorphic transient brain phenotype in maternal-zyg...

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Detalles Bibliográficos
Autores principales: Suzzi, Stefano, Ahrendt, Reiner, Hans, Stefan, Semenova, Svetlana A., Chekuru, Avinash, Wirsching, Paul, Kroehne, Volker, Bilican, Saygın, Sayed, Shady, Winkler, Sylke, Spieß, Sandra, Machate, Anja, Kaslin, Jan, Panula, Pertti, Brand, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459977/
https://www.ncbi.nlm.nih.gov/pubmed/34516550
http://dx.doi.org/10.1371/journal.pgen.1009794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459977/
https://www.ncbi.nlm.nih.gov/pubmed/34516550
http://dx.doi.org/10.1371/journal.pgen.1009794

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