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The distinct role of the four voltage sensors of the skeletal Ca(V)1.1 channel in voltage-dependent activation
Initiation of skeletal muscle contraction is triggered by rapid activation of RYR1 channels in response to sarcolemmal depolarization. RYR1 is intracellular and has no voltage-sensing structures, but it is coupled with the voltage-sensing apparatus of Ca(V)1.1 channels to inherit voltage sensitivity...
Autores principales: | Savalli, Nicoletta, Angelini, Marina, Steccanella, Federica, Wier, Julian, Wu, Fenfen, Quinonez, Marbella, DiFranco, Marino, Neely, Alan, Cannon, Stephen C., Olcese, Riccardo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460119/ https://www.ncbi.nlm.nih.gov/pubmed/34546289 http://dx.doi.org/10.1085/jgp.202112915 |
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