Cargando…

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mutants in the intraflagellar transport protein gene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerrero, Gabriel A, Derisbourg, Maxime J, Mayr, Felix AMC, Wester, Laura E, Giorda, Marco, Dinort, J Eike, Hartman, Matías D, Schilling, Klara, Alonso-De Gennaro, María José, Lu, Ryan J, Benayoun, Bérénice A, Denzel, Martin S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460253/ https://www.ncbi.nlm.nih.gov/pubmed/34448454 http://dx.doi.org/10.7554/eLife.53174

Ejemplares similares

Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity
por: Naim, Nikki, et al.
Publicado: (2021)

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
por: Derisbourg, Maxime J., et al.
Publicado: (2021)

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans
por: Heestand, Bree N., et al.
Publicado: (2013)

Epigenetic memory of longevity in Caenorhabditis elegans
por: Benayoun, Bérénice A., et al.
Publicado: (2012)

Uncoupling of Longevity and Telomere Length in C. elegans
por: Raices, Marcela, et al.
Publicado: (2005)

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans
por: Zeng, Lidan, et al.
Publicado: (2021)

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans
por: Goudeau, Jérôme, et al.
Publicado: (2011)

Correction: Uncoupling of Longevity and Telomere Length in C. elegans
por: Raices, Marcela, et al.
Publicado: (2005)

Endogenous NHR ligands: metabolomics to the rescue
por: Bethke, Axel, et al.
Publicado: (2014)

Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity
por: Crocco, Paolina, et al.
Publicado: (2019)

Evolution of Human Longevity Uncoupled from Caloric Restriction Mechanisms
por: Zhao, Guodong, et al.
Publicado: (2014)

KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
por: Herholz, Marija, et al.
Publicado: (2019)

Transgenerational Epigenetic Inheritance of Longevity in C. elegans
por: Greer, Eric L., et al.
Publicado: (2011)

Development and validation of a prediction model for early mortality after transcatheter aortic valve implantation (TAVI) based on the Netherlands Heart Registration (NHR): The TAVI‐NHR risk model
por: Al‐Farra, Hatem, et al.
Publicado: (2022)

Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation
por: Rampelli, Simone, et al.
Publicado: (2020)

The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes
por: Singh, Raksha, et al.
Publicado: (2020)

Multi-level remodeling of transcriptional landscapes in aging and longevity
por: Lai, Rochelle W., et al.
Publicado: (2019)

The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor
por: Hu, Queenie, et al.
Publicado: (2018)

Protection against APOE4-associated aging phenotypes with a longevity-promoting intervention
por: McGill, Cassandra, et al.
Publicado: (2021)

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
por: Zhou, Changcheng, et al.
Publicado: (2009)

“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism
por: van Vugt-Lussenburg, Barbara M. A., et al.
Publicado: (2022)

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity
por: Rose, Giuseppina, et al.
Publicado: (2011)

The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans
por: Peterson, Nicholas D., et al.
Publicado: (2019)

C. elegans protein interaction network analysis probes RNAi validated pro-longevity effect of nhr-6, a human homolog of tumor suppressor Nr4a1
por: Akhoon, Bashir A., et al.
Publicado: (2019)

The Role of Nuclear Receptor NHR-64 in Fat Storage Regulation in Caenorhabditis elegans
por: Liang, Bin, et al.
Publicado: (2010)

Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8
por: Otarigho, Benson, et al.
Publicado: (2020)

Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8
por: Otarigho, Benson, et al.
Publicado: (2021)

Correlations between NLR, NHR, and clinicopathological characteristics, and prognosis of acute ischemic stroke
por: Zhu, Feng, et al.
Publicado: (2023)

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
por: Keipert, Susanne, et al.
Publicado: (2011)

Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans
por: Fredens, Julius, et al.
Publicado: (2012)

Perturbations of the immune system by xenobiotics.
por: Luster, M I, et al.
Publicado: (1989)

Facile synthesis and nematicidal activity evaluation of thiophosphinyl amide [(Pz)(2)P(S)NHR] and thiophosphonyl diamide [(Pz)P(S)(NHR)(2)] (Pz = 1,3,5-trimethylpyrazole, R = biphenyl derivatives)
por: Chen, Xiao, et al.
Publicado: (2021)

Specific phytochemicals in floral nectar up‐regulate genes involved in longevity regulation and xenobiotic metabolism, extending mosquito life span
por: Njoroge, Teresia M., et al.
Publicado: (2021)

Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats
por: Migliaccio, Vincenzo, et al.
Publicado: (2019)

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
por: Tabb, Michelle M, et al.
Publicado: (2004)

The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes
por: Ménez, Cécile, et al.
Publicado: (2019)

Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway in Caenorhabditis elegans
por: Farias-Pereira, Renalison, et al.
Publicado: (2019)

Absorption and distribution of xenobiotics.
por: Standaert, F G
Publicado: (1988)

Key to Xenobiotic Carotenoids
por: Sliwka, Hans-Richard, et al.
Publicado: (2012)

Chemosensory Learning in the Cortex
por: Rolls, Edmund T.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ce15eeotcv77s4bu13pvkt2cvq