Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington’s Disease

Huntington’s disease (HD) is an adult-onset neurodegenerative disease caused by a trinucleotide CAG repeat expansion in the HTT gene. While the pathogenesis of HD is incompletely understood, mitochondrial dysfunction is thought to be a key contributor. In this work, we used C. elegans models to eluc...

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Detalles Bibliográficos
Autores principales: Machiela, Emily, Rudich, Paige D, Traa, Annika, Anglas, Ulrich, Soo, Sonja K, Senchuk, Megan M, Van Raamsdonk, Jeremy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460302/
https://www.ncbi.nlm.nih.gov/pubmed/34631219
http://dx.doi.org/10.14336/AD.2021.0404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460302/
https://www.ncbi.nlm.nih.gov/pubmed/34631219
http://dx.doi.org/10.14336/AD.2021.0404

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