AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms

The chromosomal translocation t(8;21) and the resulting oncofusion gene AML1/ETO have long served as a prototypical genetic lesion to model and understand leukemogenesis. In this review, we describe the wide-ranging role of AML1/ETO in AML leukemogenesis, with a particular focus on the aberrant epig...

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Detalles Bibliográficos
Autores principales: Rejeski, Kai, Duque-Afonso, Jesús, Lübbert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460439/
https://www.ncbi.nlm.nih.gov/pubmed/34331016
http://dx.doi.org/10.1038/s41388-021-01952-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460439/
https://www.ncbi.nlm.nih.gov/pubmed/34331016
http://dx.doi.org/10.1038/s41388-021-01952-w

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