Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075

In chronic obesity, hepatocytes become insulin resistant and exert important effects on systemic metabolism. Here we show that in early onset obesity (4wks HFD), hepatocytes secrete exosomes which enhance insulin sensitivity both in vitro and in vivo. These beneficial effects were due to exosomal mi...

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Detalles Bibliográficos
Autores principales: Ji, Yudong, Luo, Zhenlong, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Bandyopadhyay, Gautam, Jin, Zhongmou, Manda, Kameswari Ananthakrishnan, Isaac, Roi, Yang, Meixiang, Fu, Wenxian, Ying, Wei, Olefsky, Jerrold M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460610/
https://www.ncbi.nlm.nih.gov/pubmed/34489604
http://dx.doi.org/10.1038/s42255-021-00444-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460610/
https://www.ncbi.nlm.nih.gov/pubmed/34489604
http://dx.doi.org/10.1038/s42255-021-00444-1

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