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Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075
In chronic obesity, hepatocytes become insulin resistant and exert important effects on systemic metabolism. Here we show that in early onset obesity (4wks HFD), hepatocytes secrete exosomes which enhance insulin sensitivity both in vitro and in vivo. These beneficial effects were due to exosomal mi...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460610/ https://www.ncbi.nlm.nih.gov/pubmed/34489604 http://dx.doi.org/10.1038/s42255-021-00444-1 |