Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

The aggregation of alpha-synuclein (α-SYN) follows a cascade of oligomeric, prefibrillar and fibrillar forms, culminating in the formation of Lewy Bodies (LB), the pathological hallmarks of Parkinson’s Disease. Although LB contain over 70 proteins, the potential for interactions along the aggregatio...

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Detalles Bibliográficos
Autores principales: Leitão, André D. G., Rudolffi-Soto, Paulina, Chappard, Alexandre, Bhumkar, Akshay, Lau, Derrick, Hunter, Dominic J. B., Gambin, Yann, Sierecki, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460662/
https://www.ncbi.nlm.nih.gov/pubmed/34556785
http://dx.doi.org/10.1038/s42003-021-02624-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460662/
https://www.ncbi.nlm.nih.gov/pubmed/34556785
http://dx.doi.org/10.1038/s42003-021-02624-x

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