Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

Giant cell tumor of bone (GCTB) is an aggressive osteolytic bone tumor characterized by the within-tumor presence of osteoclast-like multinucleated giant cells (MGCs), which are induced by the neoplastic stromal cells and lead to extensive bone destruction. However, the underlying mechanism of the p...

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Detalles Bibliográficos
Autores principales: He, Yunfei, Cheng, Dongdong, Lian, Cheng, Liu, Yingjie, Luo, Wenqian, Wang, Yuan, Ma, Chengxin, Wu, Qiuyao, Tian, Pu, He, Dasa, Jia, Zhenchang, Lv, Xianzhe, Zhang, Xue, Pan, Zhen, Lu, Jinxi, Xiao, Yansen, Zhang, Peiyuan, Liang, Yajun, Yang, Qingcheng, Hu, Guohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460728/
https://www.ncbi.nlm.nih.gov/pubmed/34556636
http://dx.doi.org/10.1038/s41419-021-04161-1

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