Cargando…

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

Coptis chinensis is an ancient Chinese herb treating diabetes in China for thousands of years. However, its underlying mechanism remains poorly understood. Here, we report the effects of its main active component, berberine (BBR), on stimulating insulin secretion. In mice with hyperglycemia induced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Miao-Miao, Lu, Jing, Li, Sen, Wang, Hao, Cao, Xi, Li, Qi, Shi, Ting-Ting, Matsunaga, Kohichi, Chen, Chen, Huang, Haixia, Izumi, Tetsuro, Yang, Jin-Kui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460738/ https://www.ncbi.nlm.nih.gov/pubmed/34556670 http://dx.doi.org/10.1038/s41467-021-25952-2

Ejemplares similares

Author Correction: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
por: Zhao, Miao-Miao, et al.
Publicado: (2021)

Cisapride induced hypoglycemia via the KCNH6 potassium channel
por: Lu, Jing, et al.
Publicado: (2022)

Structural Properties of PAS Domains from the KCNH Potassium Channels
por: Adaixo, Ricardo, et al.
Publicado: (2013)

Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels
por: Dai, Gucan, et al.
Publicado: (2018)

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels
por: Dai, Gucan, et al.
Publicado: (2017)

Kcnh1 Voltage-gated Potassium Channels Are Essential for Early Zebrafish Development
por: Stengel, Rayk, et al.
Publicado: (2012)

Potassium Channel KCNH1 Activating Variants Cause Altered Functional and Morphological Ciliogenesis
por: Napoli, Giulia, et al.
Publicado: (2022)

Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancers
por: Zheng, Zequn, et al.
Publicado: (2023)

Association Between Serious Hypoglycemia and Calcium-Channel Blockers Used Concomitantly With Insulin Secretagogues
por: Nam, Young Hee, et al.
Publicado: (2021)

Hypolipidaemic and Insulin Secretagogue Activities of (R)-(−)-Carvone
por: Abbas, Manal Ahmad, et al.
Publicado: (2020)

Contribution of Mitochondria to Insulin Secretion by Various Secretagogues
por: Ježek, Petr, et al.
Publicado: (2022)

Growth hormone secretagogue receptor is important in the development of experimental colitis
por: Liu, Zhen-ze, et al.
Publicado: (2015)

Structure of the C-terminal Region of a KCNH Channel
por: Brelidze, Tinatin I., et al.
Publicado: (2012)

The structural mechanism of KCNH-channel regulation by the eag domain
por: Haitin, Yoni, et al.
Publicado: (2013)

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
por: Lörinczi, Éva, et al.
Publicado: (2015)

Antihyperglycemic and Insulin Secretagogue Activities of Abrus precatorius Leaf Extract
por: Umamahesh, Balekari, et al.
Publicado: (2016)

N- and C-terminal interactions in KCNH channels: The spotlight on the intrinsic ligand
por: Brelidze, Tinatin I.
Publicado: (2019)

Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
por: Codding, Sara J., et al.
Publicado: (2020)

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
por: Engelbrechtsen, Line, et al.
Publicado: (2018)

Circulating adipokines data associated with insulin secretagogue use in breast cancer patients
por: Wintrob, Zachary A.P., et al.
Publicado: (2016)

A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent
por: Sugawara, Kenji, et al.
Publicado: (2016)

Novel KCNH1 Mutations Associated with Epilepsy: Broadening the Phenotypic Spectrum of KCNH1-Associated Diseases
por: von Wrede, Randi, et al.
Publicado: (2021)

Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations
por: Zhang, Xianqin, et al.
Publicado: (2008)

The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation
por: Zhao, Yaxian, et al.
Publicado: (2017)

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels
por: Wang, Ze-Jun, et al.
Publicado: (2019)

Correction: A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent
Publicado: (2017)

Interprofessional Continuous Glucose Monitoring for Underserved Adults with Type 2 Diabetes on Insulin or Secretagogues
por: Fasina, Ife, et al.
Publicado: (2021)

Arylquin 1 (Potent Par-4 Secretagogue) Inhibits Tumor Progression and Induces Apoptosis in Colon Cancer Cells
por: Chen, Yi-Ting, et al.
Publicado: (2022)

Circulating growth factors data associated with insulin secretagogue use in women with incident breast cancer
por: Wintrob, Zachary A.P., et al.
Publicado: (2017)

Insulin secretagogue use and circulating inflammatory C–C chemokine levels in breast cancer patients
por: Wintrob, Zachary A.P., et al.
Publicado: (2017)

Dataset on granulopoiesis- and lymphopoiesis-stimulating cytokine levels in insulin secretagogue users with incident breast cancer
por: Wintrob, Zachary A.P., et al.
Publicado: (2017)

Human pulmonary macrophage-derived mucus secretagogue
Publicado: (1984)

Neuroprotective Actions of Ghrelin and Growth Hormone Secretagogues
por: Frago, Laura M., et al.
Publicado: (2011)

Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
por: Wei, Wei, et al.
Publicado: (2023)

Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells
por: Saegusa, Keiko, et al.
Publicado: (2022)

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis
por: Zhao, Kunli, et al.
Publicado: (2023)

The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation
por: Yin, Yue, et al.
Publicado: (2014)

TH1 and TH2 cytokine data in insulin secretagogues users newly diagnosed with breast cancer
por: Wintrob, Zachary A.P., et al.
Publicado: (2017)

Is KCNH1 mutation related to coronary artery ectasia
por: Noori, Mohammad Rafi, et al.
Publicado: (2019)

Clinical Feature, Treatment, and KCNH5 Mutations in Epilepsy
por: Hu, Xiufu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_635k9b4g8p3i95iovn8702djqq