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Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
The highly cytotoxic marine natural product callyspongiolide holds great promise as a warhead of antibody-drug conjugate in cancer therapeutics; however, the mechanism underlying its cytotoxicity remains unclear. To elucidate how callyspongiolide kills cells, we employed label-free target identifica...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460830/ https://www.ncbi.nlm.nih.gov/pubmed/34556786 http://dx.doi.org/10.1038/s42003-021-02643-8 |