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Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion

The highly cytotoxic marine natural product callyspongiolide holds great promise as a warhead of antibody-drug conjugate in cancer therapeutics; however, the mechanism underlying its cytotoxicity remains unclear. To elucidate how callyspongiolide kills cells, we employed label-free target identifica...

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Detalles Bibliográficos
Autores principales: Ha, Jaeyoung, Park, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460830/
https://www.ncbi.nlm.nih.gov/pubmed/34556786
http://dx.doi.org/10.1038/s42003-021-02643-8

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