Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis

Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of Alzheimer’s disease (AD). Emerging evidence has shown that antioxidant therapy represents a promising therapeutic strategy for the treatment of AD. In this study, we investigated the antioxidant activity of rhein...

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Detalles Bibliográficos
Autores principales: Yin, Zhihui, Geng, Xinyue, Zhang, Zhengyi, Wang, Ying, Gao, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461019/
https://www.ncbi.nlm.nih.gov/pubmed/34566664
http://dx.doi.org/10.3389/fphar.2021.746711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461019/
https://www.ncbi.nlm.nih.gov/pubmed/34566664
http://dx.doi.org/10.3389/fphar.2021.746711

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