Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity

Eukaryotic translation initiation factor 4B (eIF4B) plays an important role in mRNA translation initiation, cell survival and proliferation in vitro. However, its function in vivo is poorly understood. Here, we identified that eIF4B knockout (KO) in mice led to embryonic lethality, and the embryos d...

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Detalles Bibliográficos
Autores principales: Chen, Biao, Chen, Yuhai, Rai, Kul Raj, Wang, Xuefei, Liu, Shasha, Li, Yingying, Xiao, Meng, Ma, Yun, Wang, Guoqing, Guo, Guijie, Huang, Shile, Chen, Ji-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461113/
https://www.ncbi.nlm.nih.gov/pubmed/34566982
http://dx.doi.org/10.3389/fimmu.2021.723885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461113/
https://www.ncbi.nlm.nih.gov/pubmed/34566982
http://dx.doi.org/10.3389/fimmu.2021.723885

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