Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets

[Image: see text] Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electrophilic enzyme cofactors, tran...

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Detalles Bibliográficos
Autores principales: Lin, Zongtao, Wang, Xie, Bustin, Katelyn A., Shishikura, Kyosuke, McKnight, Nate R., He, Lin, Suciu, Radu M., Hu, Kai, Han, Xian, Ahmadi, Mina, Olson, Erika J., Parsons, William H., Matthews, Megan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461768/
https://www.ncbi.nlm.nih.gov/pubmed/34584954
http://dx.doi.org/10.1021/acscentsci.1c00616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461768/
https://www.ncbi.nlm.nih.gov/pubmed/34584954
http://dx.doi.org/10.1021/acscentsci.1c00616

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