Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model

Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch s...

Descripción completa

Detalles Bibliográficos
Autores principales: Chatel, Benjamin, Ducreux, Sylvie, Harhous, Zeina, Bendridi, Nadia, Varlet, Isabelle, Ogier, Augustin C., Bernard, Monique, Gondin, Julien, Rieusset, Jennifer, Westerblad, Håkan, Bendahan, David, Gineste, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461820/
https://www.ncbi.nlm.nih.gov/pubmed/34378772
http://dx.doi.org/10.1242/dmm.048981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461820/
https://www.ncbi.nlm.nih.gov/pubmed/34378772
http://dx.doi.org/10.1242/dmm.048981

Ejemplares similares