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Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model
Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch s...
Autores principales: | Chatel, Benjamin, Ducreux, Sylvie, Harhous, Zeina, Bendridi, Nadia, Varlet, Isabelle, Ogier, Augustin C., Bernard, Monique, Gondin, Julien, Rieusset, Jennifer, Westerblad, Håkan, Bendahan, David, Gineste, Charlotte |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461820/ https://www.ncbi.nlm.nih.gov/pubmed/34378772 http://dx.doi.org/10.1242/dmm.048981 |
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