Cargando…

USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4

BACKGROUND: Glioblastomas (GBMs) are grade IV central nervous system tumors characterized by a poor prognosis and a short median overall survival. Effective induction of GBM cell death is difficult because the GBM cell population is genetically unstable, resistant to chemotherapy and highly angiogen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Tingzheng, Li, Xuetao, Li, Yanyan, Tao, Zhennan, Yao, Hui, Wu, Yue, Chen, Guangliang, Zhang, Kai, Zhou, Youxin, Huang, Yulun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461901/ https://www.ncbi.nlm.nih.gov/pubmed/34556124 http://dx.doi.org/10.1186/s12935-021-02208-z

Ejemplares similares

PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1
por: Li, Xuetao, et al.
Publicado: (2023)

USP18 directly regulates Snail1 protein through ubiquitination pathway in colorectal cancer
por: Huang, Fakun, et al.
Publicado: (2020)

Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy
por: Cui, Lang, et al.
Publicado: (2020)

Arf6 regulates EGF-induced internalization of E-cadherin in breast cancer cells
por: Xu, Rui, et al.
Publicado: (2015)

Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis
por: Scicchitano, Bianca Maria, et al.
Publicado: (2018)

Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53: USP7 inhibits ubiquitination of p53
por: Li, Xu, et al.
Publicado: (2022)

EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells
por: Cui, Jing, et al.
Publicado: (2015)

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia
por: Luo, Hao, et al.
Publicado: (2019)

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region
por: Tao, Zhennan, et al.
Publicado: (2020)

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
por: Zhang, Wei, et al.
Publicado: (2020)

Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway
por: Wu, Shuai, et al.
Publicado: (2019)

Deubiquitylation and stabilization of ARMC5 by ubiquitin‐specific processing protease 7 (USP7) are critical for RCC proliferation
por: Yan, Guobei, et al.
Publicado: (2021)

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis
por: Li, Wei, et al.
Publicado: (2022)

Tre2 (USP6NL) promotes colorectal cancer cell proliferation via Wnt/β-catenin pathway
por: Sun, Kang, et al.
Publicado: (2019)

Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells
por: Hu, Yaling, et al.
Publicado: (2022)

Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1’s pro-metastatic functions in esophageal cancer
por: Li, Gang, et al.
Publicado: (2020)

TIP60 governs the auto-ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex
por: Ahmad, Tanveer, et al.
Publicado: (2021)

Histone deacetylase inhibition up-regulates MHC class I to facilitate cytotoxic T lymphocyte-mediated tumor cell killing in glioma cells
por: Sun, Ting, et al.
Publicado: (2019)

Transcriptional regulation and ubiquitination-dependent regulation of HnRNPK oncogenic function in prostate tumorigenesis
por: Wu, Huan-Lei, et al.
Publicado: (2021)

Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein
por: Deng, Li-Juan, et al.
Publicado: (2018)

Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness
por: Erbayraktar, Zubeyde, et al.
Publicado: (2016)

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1
por: Zhu, Fei, et al.
Publicado: (2020)

HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination
por: Li, T, et al.
Publicado: (2014)

RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication
por: Chang, Ya-Chu, et al.
Publicado: (2023)

N-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87
por: Hanif, Farina, et al.
Publicado: (2014)

Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF
por: Lo, Dorothy, et al.
Publicado: (2014)

MicroRNA-365 promotes lung carcinogenesis by downregulating the USP33/SLIT2/ROBO1 signalling pathway
por: Wang, Yuhuan, et al.
Publicado: (2018)

USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis
por: Takahashi, Masahiko, et al.
Publicado: (2018)

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
por: Fang, Xiaoguang, et al.
Publicado: (2017)

Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7
por: Huang, He, et al.
Publicado: (2021)

TRIM47 promotes malignant progression of renal cell carcinoma by degrading P53 through ubiquitination
por: Chen, Jia-xin, et al.
Publicado: (2021)

Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
por: O’Dea, Rachel, et al.
Publicado: (2023)

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response
por: Du, Shi-chun, et al.
Publicado: (2019)

miR-218-5p inhibits the stem cell properties and invasive ability of the A2B5+CD133- subgroup of human glioma stem cells
por: Wu, Zhiwu, et al.
Publicado: (2022)

USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A(165b) alternative splicing via regulating SRSF1 and SRPK1
por: Pan, Xiu-wu, et al.
Publicado: (2021)

Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma
por: Yu, Kai, et al.
Publicado: (2021)

Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7
por: Lee, Alvin Teck Chien, et al.
Publicado: (2003)

Identification of potential biomarkers and candidate small molecule drugs in glioblastoma
por: Lu, Wei-cheng, et al.
Publicado: (2020)

MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7
por: Xia, Wei, et al.
Publicado: (2017)

Disrupting the CXCL12/CXCR4 axis disturbs the characteristics of glioblastoma stem-like cells of rat RG2 glioblastoma
por: Lee, Chin-Cheng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ck2ur6nqj8p5rfs4otmlmt0i6i