Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been re...

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Detalles Bibliográficos
Autores principales: Silva, Ana, Almeida, Afonso R. M., Cachucho, Ana, Neto, João L., Demeyer, Sofie, de Matos, Mafalda, Hogan, Thea, Li, Yunlei, Meijerink, Jules, Cools, Jan, Grosso, Ana Rita, Seddon, Benedict, Barata, João T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462360/
https://www.ncbi.nlm.nih.gov/pubmed/33970999
http://dx.doi.org/10.1182/blood.2019000553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462360/
https://www.ncbi.nlm.nih.gov/pubmed/33970999
http://dx.doi.org/10.1182/blood.2019000553

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