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Pericyte Insulin Receptors Modulate Retinal Vascular Remodeling and Endothelial Angiopoietin Signaling
Pericytes regulate vascular development, stability, and quiescence; their dysfunction contributes to diabetic retinopathy. To explore the role of insulin receptors in pericyte biology, we created pericyte insulin receptor knockout mice (PIRKO) by crossing PDGFRβ-Cre mice with insulin receptor (Insr)...
Autores principales: | Warmke, Nele, Platt, Fiona, Bruns, Alexander F, Ozber, Claire H, Haywood, Natalie J, Abudushalamu, Yilizila, Slater, Charles, Palin, Victoria, Sukumar, Piruthivi, Wheatcroft, Stephen B, Yuldasheva, Nadira Y, Kearney, Mark T, Griffin, Kathryn J, Cubbon, Richard M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462386/ https://www.ncbi.nlm.nih.gov/pubmed/34460911 http://dx.doi.org/10.1210/endocr/bqab182 |
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