Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia

The abundance of genetic abnormalities and phenotypic heterogeneities in acute myeloid leukemia (AML) poses significant challenges to the development of improved treatments. Here, we demonstrated that a key growth arrest-specific gene 6/AXL axis is highly activated in cells from patients with AML, p...

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Detalles Bibliográficos
Autores principales: Niu, Xiaojia, Rothe, Katharina, Chen, Min, Grasedieck, Sarah, Li, Rick, Nam, Sung-Eun, Zhang, Xiuyan, Novakovskiy, German E., Ahn, Ye-Hyeon, Maksakova, Irina, Lai, Shenshen, Zhang, Hong, Yan, Jun, Liu, Hong, Zhao, Yun, Wu, Depei, Ge, Yubin, Wasserman, Wyeth W., Rouhi, Arefeh, Kuchenbauer, Florian, Yip, Calvin K., Zhang, Zaihui, Jiang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462401/
https://www.ncbi.nlm.nih.gov/pubmed/33786587
http://dx.doi.org/10.1182/blood.2020007651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462401/
https://www.ncbi.nlm.nih.gov/pubmed/33786587
http://dx.doi.org/10.1182/blood.2020007651

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