Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

Venetoclax is a highly potent, selective BCL2 inhibitor capable of inducing apoptosis in cells dependent on BCL2 for survival. Most myeloma is MCL1-dependent; however, a subset of myeloma enriched for translocation t(11;14) is codependent on BCL2 and thus sensitive to venetoclax. The biology underly...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Vikas A., Barwick, Benjamin G., Matulis, Shannon M., Shirasaki, Ryosuke, Jaye, David L., Keats, Jonathan J., Oberlton, Benjamin, Joseph, Nisha S., Hofmeister, Craig C., Heffner, Leonard T., Dhodapkar, Madhav V., Nooka, Ajay K., Lonial, Sagar, Mitsiades, Constantine S., Kaufman, Jonathan L., Boise, Lawrence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462405/
https://www.ncbi.nlm.nih.gov/pubmed/33649772
http://dx.doi.org/10.1182/blood.2020007899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462405/
https://www.ncbi.nlm.nih.gov/pubmed/33649772
http://dx.doi.org/10.1182/blood.2020007899

Ejemplares similares