A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes

The B cells in our body generate protective antibodies by introducing somatic hypermutations (SHM) into the variable region of immunoglobulin genes (IgVs). The mutations are generated by activation induced deaminase (AID) that converts cytosine to uracil in single stranded DNA (ssDNA) generated duri...

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Detalles Bibliográficos
Autores principales: Yu, Guojun, Wu, Yingru, Duan, Zhi, Tang, Catherine, Xing, Haipeng, Scharff, Matthew D., MacCarthy, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462741/
https://www.ncbi.nlm.nih.gov/pubmed/34491985
http://dx.doi.org/10.1371/journal.pcbi.1009323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462741/
https://www.ncbi.nlm.nih.gov/pubmed/34491985
http://dx.doi.org/10.1371/journal.pcbi.1009323

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