Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor

The common deletion of the third exon of the growth hormone receptor gene (GHRd3) in humans is associated with birth weight, growth after birth, and time of puberty. However, its evolutionary history and the molecular mechanisms through which it affects phenotypes remain unresolved. We present evide...

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Detalles Bibliográficos
Autores principales: Saitou, Marie, Resendez, Skyler, Pradhan, Apoorva J., Wu, Fuguo, Lie, Natasha C., Hall, Nancy J., Zhu, Qihui, Reinholdt, Laura, Satta, Yoko, Speidel, Leo, Nakagome, Shigeki, Hanchard, Neil A., Churchill, Gary, Lee, Charles, Atilla-Gokcumen, G. Ekin, Mu, Xiuqian, Gokcumen, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462886/
https://www.ncbi.nlm.nih.gov/pubmed/34559564
http://dx.doi.org/10.1126/sciadv.abi4476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462886/
https://www.ncbi.nlm.nih.gov/pubmed/34559564
http://dx.doi.org/10.1126/sciadv.abi4476

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