UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

Ubiquitin-fold modifier 1 (UFM1) is involved in neural and erythroid development, yet its biological roles in these processes are unknown. Here, we generated zebrafish models deficient in Ufm1 and Ufl1 that exhibited telomere shortening associated with developmental delay, impaired hematopoiesis and...

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Detalles Bibliográficos
Autores principales: Lee, Lara, Perez Oliva, Ana Belen, Martinez-Balsalobre, Elena, Churikov, Dmitri, Peter, Joshua, Rahmouni, Dalicya, Audoly, Gilles, Azzoni, Violette, Audebert, Stephane, Camoin, Luc, Mulero, Victoriano, Cayuela, Maria L., Kulathu, Yogesh, Geli, Vincent, Lachaud, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462904/
https://www.ncbi.nlm.nih.gov/pubmed/34559557
http://dx.doi.org/10.1126/sciadv.abc7371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462904/
https://www.ncbi.nlm.nih.gov/pubmed/34559557
http://dx.doi.org/10.1126/sciadv.abc7371

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