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Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL, which are developmentally targeted to the intesti...

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Detalles Bibliográficos
Autores principales: Brenes, Alejandro J, Vandereyken, Maud, James, Olivia J, Watt, Harriet, Hukelmann, Jens, Spinelli, Laura, Dikovskaya, Dina, Lamond, Angus I, Swamy, Mahima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463072/
https://www.ncbi.nlm.nih.gov/pubmed/34473623
http://dx.doi.org/10.7554/eLife.70055