Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach

BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, which currently lacks disease-modifying therapy to slow down its progression. Idebenone, a coenzyme Q10 (CQ10) analogue, is a well-known antioxidant and has been used to treat neurological disord...

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Detalles Bibliográficos
Autores principales: He, Pei Kun, Gao, Yu Yuan, Lyu, Feng-Juan, Chen, Jia Ning, Zhang, Yu Hu, Nie, Kun, Zhang, Qing Xi, Huang, Rui, Duan, Qing Rui, Guo, Man Li, Liu, Zhi Hua, Huang, He Ling, Ma, Gui Xian, Wang, Li Juan, Wang, Li Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463184/
https://www.ncbi.nlm.nih.gov/pubmed/34567221
http://dx.doi.org/10.1155/2021/8548380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463184/
https://www.ncbi.nlm.nih.gov/pubmed/34567221
http://dx.doi.org/10.1155/2021/8548380

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