Facile synthesis of insulin fusion derivatives through sortase A ligation

Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to retain insulin bioactivity. New and efficient metho...

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Detalles Bibliográficos
Autores principales: Disotuar, Maria M., Smith, Jake A., Li, Jinze, Alam, Steve, Lin, Nai-Pin, Chou, Danny Hung-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463260/
https://www.ncbi.nlm.nih.gov/pubmed/34589392
http://dx.doi.org/10.1016/j.apsb.2020.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463260/
https://www.ncbi.nlm.nih.gov/pubmed/34589392
http://dx.doi.org/10.1016/j.apsb.2020.11.011

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