Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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Detalles Bibliográficos
Autores principales: Al-Hamashi, Ayad A., Chen, Dongxing, Deng, Youchao, Dong, Guangping, Huang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463262/
https://www.ncbi.nlm.nih.gov/pubmed/34589391
http://dx.doi.org/10.1016/j.apsb.2020.10.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463262/
https://www.ncbi.nlm.nih.gov/pubmed/34589391
http://dx.doi.org/10.1016/j.apsb.2020.10.013

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