Cargando…

Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Hamashi, Ayad A., Chen, Dongxing, Deng, Youchao, Dong, Guangping, Huang, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463262/ https://www.ncbi.nlm.nih.gov/pubmed/34589391 http://dx.doi.org/10.1016/j.apsb.2020.10.013

Ejemplares similares

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
por: Iyamu, Iredia D., et al.
Publicado: (2021)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
por: Gao, Yongzhi, et al.
Publicado: (2019)

Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1
por: Dong, Guangping, et al.
Publicado: (2022)

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics
por: Gao, Yongzhi, et al.
Publicado: (2021)

Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase
por: Jung, Eunkyung, et al.
Publicado: (2022)

Deactivatable Bisubstrate Inhibitors of Protein Kinases
por: Sõrmus, Tanel, et al.
Publicado: (2022)

Bisubstrate analogues as structural tools to investigate m(6)A methyltransferase active sites
por: Oerum, Stephanie, et al.
Publicado: (2019)

Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase
por: Zhou, Jujun, et al.
Publicado: (2023)

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
por: Iannelli, Giulia, et al.
Publicado: (2022)

Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80
por: Myklebust, Line M., et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy
por: Tang, Yixuan, et al.
Publicado: (2022)

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
por: Borodkin, Vladimir S., et al.
Publicado: (2014)

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6
por: Gong, Shuai, et al.
Publicado: (2021)

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family
por: Nonga, Olivier E., et al.
Publicado: (2021)

Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors
por: Dobrescu, Irina, et al.
Publicado: (2023)

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
por: Kong, Gui-Mei, et al.
Publicado: (2017)

A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
por: Deng, Youchao, et al.
Publicado: (2023)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological Evaluation
por: Hu, Hao, et al.
Publicado: (2015)

Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines
por: Zhao, Dong-Fang, et al.
Publicado: (2021)

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
por: Devkota, Kanchan, et al.
Publicado: (2021)

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites
por: Nardella, Flore, et al.
Publicado: (2019)

Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1
por: Cao, Meng-Tong, et al.
Publicado: (2023)

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
por: Zhang, Jing, et al.
Publicado: (2022)

Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors
por: Brown, Tyler, et al.
Publicado: (2022)

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1
por: Yan, Leilei, et al.
Publicado: (2014)

Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression
por: Busacca, Sara, et al.
Publicado: (2021)

Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo
por: Zhang, Baolai, et al.
Publicado: (2018)

Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
por: Kanwal, Rajnee, et al.
Publicado: (2016)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review
por: Feustel, Kavanya, et al.
Publicado: (2022)

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
por: Ma, Anqi, et al.
Publicado: (2014)

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
por: Shailesh, Harshita, et al.
Publicado: (2018)

Correction: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
por: Kanwal, Rajnee, et al.
Publicado: (2016)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

Protein Arginine Methyltransferase 5 Functions via Interacting Proteins
por: Liang, Zhenzhen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8hfvv2qlr7pv5lobnue2giv60d