Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease

Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have indicated that Sonic Hedgehog (Shh) and the H...

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Detalles Bibliográficos
Autores principales: Yánez, Diana C., Papaioannou, Eleftheria, Chawda, Mira M., Rowell, Jasmine, Ross, Susan, Lau, Ching-In, Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463265/
https://www.ncbi.nlm.nih.gov/pubmed/34580585
http://dx.doi.org/10.3389/fimmu.2021.737245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463265/
https://www.ncbi.nlm.nih.gov/pubmed/34580585
http://dx.doi.org/10.3389/fimmu.2021.737245

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