A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

ω-Conotoxins inhibit N-type voltage-gated calcium (Ca(V)2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which consists of 25 amino acid residues and three disulfi...

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Detalles Bibliográficos
Autores principales: Chen, Jinqin, Liu, Xinhong, Yu, Shuo, Liu, Jia, Chen, Rongfang, Zhang, Yunxiao, Jiang, Ling, Dai, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463271/
https://www.ncbi.nlm.nih.gov/pubmed/34589389
http://dx.doi.org/10.1016/j.apsb.2021.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463271/
https://www.ncbi.nlm.nih.gov/pubmed/34589389
http://dx.doi.org/10.1016/j.apsb.2021.03.001

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