Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues

Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities. To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity, de novo synthesis of cyathane diterpenes in a geranylgeranyl pyrophosphate engineered Saccharomyce...

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Detalles Bibliográficos
Autores principales: Ma, Ke, Zhang, Yuting, Guo, Cui, Yang, Yanlong, Han, Junjie, Yu, Bo, Yin, Wenbing, Liu, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463280/
https://www.ncbi.nlm.nih.gov/pubmed/34589407
http://dx.doi.org/10.1016/j.apsb.2021.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463280/
https://www.ncbi.nlm.nih.gov/pubmed/34589407
http://dx.doi.org/10.1016/j.apsb.2021.04.014

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