Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds o...

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Detalles Bibliográficos
Autores principales: Sabater-Arcis, Maria, Bargiela, Ariadna, Moreno, Nerea, Poyatos-Garcia, Javier, Vilchez, Juan J., Artero, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463325/
https://www.ncbi.nlm.nih.gov/pubmed/34589284
http://dx.doi.org/10.1016/j.omtn.2021.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463325/
https://www.ncbi.nlm.nih.gov/pubmed/34589284
http://dx.doi.org/10.1016/j.omtn.2021.08.010

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