Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

Peptide inhibition of the interactions of the tumor suppressor protein P53 with its negative regulators MDM2 and MDMX activates P53 in vitro and in vivo, representing a viable therapeutic strategy for cancer treatment. Using phage display techniques, we previously identified a potent peptide activat...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Gohain, Neelakshi, Chen, Si, Li, Yinghua, Zhao, Xiaoyuan, Li, Bo, Tolbert, William D., He, Wangxiao, Pazgier, Marzena, Hu, Honggang, Lu, Wuyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463443/
https://www.ncbi.nlm.nih.gov/pubmed/34589387
http://dx.doi.org/10.1016/j.apsb.2021.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463443/
https://www.ncbi.nlm.nih.gov/pubmed/34589387
http://dx.doi.org/10.1016/j.apsb.2021.06.010

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