A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, and reproduction. Whether these pleiotropic effects...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hae-Eun H., Hwang, Wooseon, Ham, Seokjin, Kim, Eunah, Altintas, Ozlem, Park, Sangsoon, Son, Heehwa G., Lee, Yujin, Lee, Dongyeop, Heo, Won Do, Lee, Seung-Jae V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463539/
https://www.ncbi.nlm.nih.gov/pubmed/34561453
http://dx.doi.org/10.1038/s41467-021-25920-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463539/
https://www.ncbi.nlm.nih.gov/pubmed/34561453
http://dx.doi.org/10.1038/s41467-021-25920-w

Ejemplares similares