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Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a

Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of pro-survival kinase AKT, which led us to inves...

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Detalles Bibliográficos
Autores principales: Rutherford, Taylor R., Elder, Alan M., Lyons, Traci R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463677/
https://www.ncbi.nlm.nih.gov/pubmed/34561423
http://dx.doi.org/10.1038/s41419-021-04133-5