Directed evolution of rRNA improves translation kinetics and recombinant protein yield

In bacteria, ribosome kinetics are considered rate-limiting for protein synthesis and cell growth. Enhanced ribosome kinetics may augment bacterial growth and biomanufacturing through improvements to overall protein yield, but whether this can be achieved by ribosome-specific modifications remains u...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Fan, Bratulić, Siniša, Costello, Alan, Miettinen, Teemu P., Badran, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463689/
https://www.ncbi.nlm.nih.gov/pubmed/34561441
http://dx.doi.org/10.1038/s41467-021-25852-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463689/
https://www.ncbi.nlm.nih.gov/pubmed/34561441
http://dx.doi.org/10.1038/s41467-021-25852-5

Ejemplares similares