Controlling for human population stratification in rare variant association studies

Population stratification is a confounder of genetic association studies. In analyses of rare variants, corrections based on principal components (PCs) and linear mixed models (LMMs) yield conflicting conclusions. Studies evaluating these approaches generally focused on limited types of structure an...

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Detalles Bibliográficos
Autores principales: Bouaziz, Matthieu, Mullaert, Jimmy, Bigio, Benedetta, Seeleuthner, Yoann, Casanova, Jean-Laurent, Alcais, Alexandre, Abel, Laurent, Cobat, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463695/
https://www.ncbi.nlm.nih.gov/pubmed/34561511
http://dx.doi.org/10.1038/s41598-021-98370-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463695/
https://www.ncbi.nlm.nih.gov/pubmed/34561511
http://dx.doi.org/10.1038/s41598-021-98370-5

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