New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the presence of tyrosine kinase BCR-ABL1 fusion protein, which deregulate transcription and mRNA translation. Tyrosine kinase inhibitors (TKIs) are the first-choice treatment. However, resistance to TKIs remains a challenge to...

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Detalles Bibliográficos
Autores principales: Ianniello, Zaira, Sorci, Melissa, Ceci Ginistrelli, Lavinia, Iaiza, Alessia, Marchioni, Marcella, Tito, Claudia, Capuano, Ernestina, Masciarelli, Silvia, Ottone, Tiziana, Attrotto, Cristina, Rizzo, Manuela, Franceschini, Luca, de Pretis, Stefano, Voso, Maria Teresa, Pelizzola, Mattia, Fazi, Francesco, Fatica, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463696/
https://www.ncbi.nlm.nih.gov/pubmed/34561421
http://dx.doi.org/10.1038/s41419-021-04169-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463696/
https://www.ncbi.nlm.nih.gov/pubmed/34561421
http://dx.doi.org/10.1038/s41419-021-04169-7

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